Salt and Aldosterone - Reciprocal and Combined Effects in Preclinical Models and Humans.

Primary aldosteronism is an endocrine disorder caused by excessive production of aldosterone by the adrenal glands, which is recognized as the most important cause of endocrine hypertension. In addition, is represents a potentially curable form of hypertension. The independent role of high salt intake as a mediator of cardiovascular disease has been confirmed. Observational and experimental data suggest that aldosterone-induced organ damage requires plasma aldosterone levels to be inappropriate for salt status. Therefore, understanding the relationship between plasma aldosterone levels and dietary salt intake and the interaction between the two is crucial for developing effective prevention and treatment strategies. In this review, we present an update on findings about primary aldosteronism and salt intake and the underlying mechanisms governing their interaction.