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Age-Dependent RGS5 Loss in Pericytes Induces Cardiac Dysfunction and Fibrosis.

Anita TamiatoLukas S TomborAriane FischerMarion Muhly-ReinholzLeah Rebecca VanicekBüşra Nur ToğruJessica NeitzSimone Franziska GlaserMaximilian MertenDavid Rodríguez MoralesJeonghyeon KwonStephan KlattBianca SchumacherStefan GüntherWesley Tyler AbplanalpDavid JohnIngrid FlemingNina WettschureckStefanie DimmelerGuillermo Luxán
Published in: Circulation research (2024)
Our results have identified RGS5 as a crucial regulator of pericyte function during cardiac aging. The deletion of RGS5 causes cardiac dysfunction and induces myocardial fibrosis, one of the hallmarks of cardiac aging.
Keyphrases
  • left ventricular
  • oxidative stress
  • transcription factor
  • heart failure