The mGluR2/3 agonist LY379268 reverses NMDA receptor antagonist effects on cortical gamma oscillations and phase coherence, but not working memory impairments, in mice.

Elysia SokolenkoMatthew R HudsonJess NithianantharajahNigel Charles Jones

Published in: Journal of psychopharmacology (Oxford, England) (2019)

NMDA receptor antagonism impairs working memory in mice, but this is not reversed by stimulation of mGluR2/3. Since elevations in ongoing gamma power and regional coherence caused by MK-801 were improved by LY379268, it appears unlikely that these specific oscillatory abnormalities underlie the working memory impairment caused by NMDAr antagonism.

Keyphrases

working memory
transcranial direct current stimulation
attention deficit hyperactivity disorder
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