Radiosynthesis and evaluation of [18F]FMTP, a COX-2 PET ligand.
J S Dileep KumarJaya PrabhakaranAndrei MolotkovAnirudh SattirajuJongho KimMikhail DoubrovinJ John MannAkiva MintzPublished in: Pharmacological reports : PR (2020)
Specific binding to COX-2 in BxPC3 cell lines, BBB permeability, and increased brain uptake in neuroinflammation mice qualifies [18F]FMTP as a potential PET tracer for studying inflammation.
Keyphrases
- pet imaging
- positron emission tomography
- computed tomography
- pet ct
- cerebral ischemia
- blood brain barrier
- oxidative stress
- traumatic brain injury
- resting state
- white matter
- lipopolysaccharide induced
- endothelial cells
- lps induced
- functional connectivity
- high fat diet induced
- multiple sclerosis
- type diabetes
- human health
- risk assessment
- adipose tissue
- skeletal muscle