P-tau and neurodegeneration mediate the effect of β-amyloid on cognition in non-demented elders.

Ling-Zhi MaHao HuZuo-Teng WangYa-Nan OuQiang DongLan TanJin-Tai Yu

Published in: Alzheimer's research & therapy (2021)

In conclusion, early Aβ accumulation has an independent effect on cognitive decline in CN and a tau, neurodegeneration-dependent effect in the subsequent cognitive decline in MCI patients.

Keyphrases

cognitive decline
mild cognitive impairment
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
cerebrospinal fluid
prognostic factors
lymph node metastasis
patient reported outcomes