Harnessing regulatory T cells to establish immune tolerance.
Patrick HoEllen Cahir-McFarlandJason D FontenotTracey LodieAdel NadaQizhi TangLaurence A TurkaJeffrey A BluestonePublished in: Science translational medicine (2024)
Engineered regulatory T (T reg ) cells have emerged as precision therapeutics aimed at inducing immune tolerance while reducing the risks associated with generalized immunosuppression. This Viewpoint highlights the opportunities and challenges for engineered T reg cell therapies in treating autoimmune and other inflammatory diseases.