Harnessing regulatory T cells to establish immune tolerance.

Patrick Ho Ellen Cahir-McFarland Jason D Fontenot Tracey LodieAdel NadaQizhi TangLaurence A TurkaJeffrey A Bluestone

Published in: Science translational medicine (2024)

Engineered regulatory T (T reg ) cells have emerged as precision therapeutics aimed at inducing immune tolerance while reducing the risks associated with generalized immunosuppression. This Viewpoint highlights the opportunities and challenges for engineered T reg cell therapies in treating autoimmune and other inflammatory diseases.

Keyphrases

regulatory t cells
induced apoptosis
dendritic cells
single cell
cell cycle arrest
oxidative stress
multiple sclerosis
cell therapy
small molecule
cell death
endoplasmic reticulum stress
machine learning
drug induced
deep learning