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Deep mixed model for marginal epistasis detection and population stratification correction in genome-wide association studies.

Haohan WangTianwei YueJingkang YangWei WuEric P Xing
Published in: BMC bioinformatics (2019)
After validating the performance of our method using simulation experiments, we further apply it to Alzheimer's disease data sets. Our results help gain some explorative understandings of the genetic architecture of Alzheimer's disease.
Keyphrases
  • genome wide association
  • cognitive decline
  • electronic health record
  • gene expression
  • machine learning