Cyst stem cell lineage eIF5 non-autonomously prevents testicular germ cell tumor formation via eIF1A/eIF2γ-mediated pre-initiation complex.

Zhiran LiYunhao WuYangbo FuXia ChenXi ZhaoXiaolong WuYajuan LuHui HeCong ShenBo ZhengJun YuFei Sun

Published in: Stem cell research & therapy (2022)

These findings demonstrated that CySC lineage eIF5, together with eIF1A or eIF2γ, mediates soma-germline communications for the stem cell niche homeostasis in Drosophila testes, providing new insights for the prevention of TGCTs.

Keyphrases

stem cells
germ cell
dna damage
cell fate