Oxidative Dehydrogenative Coupling of Thiols with Alkanes for the Synthesis of Sulfoxides.

Yu-Jian HouYi LiZhi-Wei ZhaoTai-Gang FanBo-Xun SunXu-Nan WangYa-Min Li

Published in: Organic letters (2023)

An oxidative dehydrogenative coupling of thiols with alkanes via direct C(sp 3 )-H bond functionalization to form a new C-S bond and S═O double bond was developed. The present reaction features the use of readily available reagents and high step- and atom-efficiency, thus providing an efficient access to sulfoxides. A possible mechanism is proposed.

Keyphrases

electron transfer
room temperature
transition metal
molecular dynamics