Login / Signup

Non-Anticoagulant Low Molecular Weight Heparins for Pharmaceutical Applications.

Yilan OuyangYanlei YuFuming ZhangJianle ChenXiaorui HanKe XiaYiming YaoZhenqing ZhangRobert J Linhardt
Published in: Journal of medicinal chemistry (2019)
Heparin is a polypharmacological agent with anticoagulant activity. Periodate oxidation of the nonsulfated glucuronic acid residue results in non-anticoagulant heparin derivative (NACH) of reduced molecular weight. Similar treatment of a low molecular weight heparin, dalteparin, also removes its anticoagulant activity, affording a second heparin derivative (D-NACH). A full structural characterization of these two derivatives reveals their structural differences. SPR studies display their ability to bind to several important heparin-binding proteins, suggesting potential new therapeutic applications.
Keyphrases
  • venous thromboembolism
  • atrial fibrillation
  • growth factor
  • nitric oxide
  • replacement therapy