A Network Pharmacology Approach to Reveal the Underlying Mechanisms of Artemisia annua on the Treatment of Hepatocellular Carcinoma.
Shuqiao ZhangZhuomao MoShi-Jun ZhangXinyu LiPublished in: Evidence-based complementary and alternative medicine : eCAM (2021)
The anticancer effects of AA on HCC were predicted to be associated with regulating tumor cell proliferation, apoptosis, angiogenesis, tumor invasion, and metastasis via various pathways such as the EGFR signaling pathway, ESR1 signaling pathway, and CCND1 signaling pathway. It is suggested that AA might be developed as a broad-spectrum antitumor drug based on its characteristics of multicomponent, multipath, and multitarget.
Keyphrases
- signaling pathway
- pi k akt
- cell proliferation
- cell cycle arrest
- epithelial mesenchymal transition
- induced apoptosis
- small cell lung cancer
- oxidative stress
- cell death
- endothelial cells
- cell cycle
- epidermal growth factor receptor
- single cell
- estrogen receptor
- emergency department
- vascular endothelial growth factor
- dna methylation
- smoking cessation