The Killer's Web: Interconnection between Inflammation, Epigenetics and Nutrition in Cancer.
Marisabel MeccaSimona PicernoSalvatore CortellinoPublished in: International journal of molecular sciences (2024)
Inflammation is a key contributor to both the initiation and progression of tumors, and it can be triggered by genetic instability within tumors, as well as by lifestyle and dietary factors. The inflammatory response plays a critical role in the genetic and epigenetic reprogramming of tumor cells, as well as in the cells that comprise the tumor microenvironment. Cells in the microenvironment acquire a phenotype that promotes immune evasion, progression, and metastasis. We will review the mechanisms and pathways involved in the interaction between tumors, inflammation, and nutrition, the limitations of current therapies, and discuss potential future therapeutic approaches.
Keyphrases
- induced apoptosis
- oxidative stress
- inflammatory response
- cell cycle arrest
- physical activity
- genome wide
- stem cells
- dna methylation
- endoplasmic reticulum stress
- metabolic syndrome
- cardiovascular disease
- gene expression
- cell death
- copy number
- papillary thyroid
- lipopolysaccharide induced
- current status
- toll like receptor
- climate change
- lymph node metastasis