Thyroid hormone induces ossification and terminal maturation in a preserved OA cartilage biomimetic model.
N M KorthagenE HoutmanI BooneR Coutinho de AlmeidaK SivasubramaniyanR MahdadR G H H NelissenY F M RamosM A TessariIngrid MeulenbeltPublished in: Arthritis research & therapy (2024)
RNA-sequencing results show that metabolic activation and recuperation of growth plate morphology are induced by T3 in OA chondrocytes, indicating terminal maturation is accelerated. The molecular mechanisms involved in hypertrophy were linked to all stages of OA pathophysiology and will be used to validate disease models for drug testing.