Novel 20% doxycycline-loaded PLGA nanospheres as adjunctive therapy in chronic periodontitis in type-2 diabetics: randomized clinical, immune and microbiological trial.
Giovana LecioFernanda Vieira RibeiroSuzana Peres PimentelAurélio Amorin ReisRafaela Videira Clima da SilvaFrancisco Nociti-JrLucas MouraEliane DuekMarcio CasatiRenato Correa Viana CasarinPublished in: Clinical oral investigations (2019)
The use of locally applied doxycycline nanospheres may represent an adjunctive therapeutic approach in the treatment of periodontal disease in type-2 diabetic patients, achieving additional benefits in the local modulation of cytokines, microbial reduction, and clinical parameters, especially in deep pockets.