Notch Signaling Mediates Radiation-Induced Smooth Muscle Cell Hypermuscularization and Cerebral Vasculopathy.
Yuhua YangHonghong LiYongteng XuJiatian XieQiang LiuZhongshan ShiJialin HuangJinping ChengSiqi ChenSitai ChenXiaohui ZhaoShaojian LiZhan ZhangJinhua CaiBaixuan HeWei-Jye LinQingyu ShenYi LiYamei TangPublished in: Stroke (2022)
Radiation-induced cerebral vasculopathy showed bead-like shape and increased contractile state. Inhibition of Notch signaling by N-[N-(3, 5-difluorophenacetyl)-l-alanyl]-s-phenylglycinet-butyl ester effectively attenuated vasculopathy and relieved cognitive impairment, suggesting Notch signaling as a therapeutic target for the treatment of RIBI.