Targeted disruption of the iNOS gene improves adipose tissue inflammation and fibrosis in leptin-deficient ob/ob mice: role of tenascin C.

S BecerrilAmaia RodríguezV CatalánL Méndez-GiménezB RamírezN SáinzM LlorenteX UnamunoJavier Gómez-AmbrosiG Frühbeck

Published in: International journal of obesity (2005) (2018)

Ablation of iNOS in leptin-deficient mice improved AT inflammation and ECM remodeling-related genes, attenuating fibrosis, and metabolic dysfunction. The activation of iNOS by leptin is necessary for the synthesis and secretion of TNC in adipocytes, suggesting an important role of this alarmin in the development of AT inflammation and fibrosis.

Keyphrases

oxidative stress
adipose tissue
nitric oxide synthase
insulin resistance
high fat diet induced
liver fibrosis
type diabetes
gene expression
dna methylation
extracellular matrix
atrial fibrillation
radiofrequency ablation
skeletal muscle