Prolonged intestinal transit and diarrhea in patients with an activating GUCY2C mutation.
Hilde Løland von VolkmannIngeborg BrønstadOdd Helge GiljaRune R TronstadDag Andre SangnesRagnar NortvedtTrygve HauskenGeorg DimcevskiTorunn FiskerstrandKim NylundPublished in: PloS one (2017)
Despite having diarrhea, the FGDS patients have prolonged transit time through the gut compared to HC, particularly in colon. The reduced number of intestinal contractions and lack of 5-HT release after a meal in FGDS patients surprisingly resemble colonic motility disturbances seen in patients with constipation.