Interaction of bacterial genera associated with therapeutic response to immune checkpoint PD-1 blockade in a United States cohort.
Rachel C NewsomeRaad Z GharaibehChristine M PierceWildson Vieira da SilvaShirlene PaulStephanie R HogueQin YuScott AntoniaJose R Conejo-GarciaLary A RobinsonChristian JobinPublished in: Genome medicine (2022)
The role of isolate-specific function and bacterial gene expression in gut microbial-driven responsiveness to ICI has been underappreciated. This work supports further investigation using isolate-driven models to characterize the mechanisms underlying this phenomenon.