Nociceptive and Transcriptomic Responses in a Swine Diabetic Wound Model Treated With a Topical AT1R Antagonist.

In this study, wounds modeling diabetic ulcers were created in hyperglycemic swine and treated with a topical AT1R antagonist. Treated wounds had a higher tolerance threshold for thermal hyperalgesia but not mechanical allodynia. Pathway analysis of differentially expressed genes revealed several pathways of interest for future pain research. Although further studies are needed to confirm the findings, this study can improve nursing care of diabetic wounds by providing information about a potential future treatment that may be used to decrease pain and improve HRQOL in patients with diabetic wounds.