A Randomized Trial of Progesterone in Women with Bleeding in Early Pregnancy.
Arri CoomarasamyAdam J DevallVersha CheedHoda HarbLee J MiddletonIoannis D GallosHelen WilliamsAbey K EapenTracy RobertsChriscasimir C OgwuluIlias GoranitisJane P DanielsAmna AhmedRuth Bender-AtikKalsang BhatiaCecilia BottomleyJane BrewinMeenakshi ChoudharyFiona CrosfillShilpa DebW Colin DuncanAndrew EwerKim HinshawTom HollandFeras IzzatJemma JohnsKathiuska KriedtMary-Ann LumsdenPadma MandaJane E NormanNatalie NunesCaroline E OvertonSiobhan QuenbySandhya RaoJackie RossAnupama ShahidMartyn UnderwoodNirmala VaithilingamLinda WatkinsCatherine WykesAndrew W HorneDavor JurkovicPublished in: The New England journal of medicine (2019)
Among women with bleeding in early pregnancy, progesterone therapy administered during the first trimester did not result in a significantly higher incidence of live births than placebo. (Funded by the United Kingdom National Institute for Health Research Health Technology Assessment program; PRISM Current Controlled Trials number, ISRCTN14163439.).