Maternal nutrition and metabolic health status during pregnancy are critical factors that shape the life-long health trajectory of offspring. Altered nutrition during specific times of development in utero can lead to functional changes in tissues such as the pancreatic β-cells, predisposing those tissues to metabolic diseases and Type 2 diabetes that manifest later in life. This chapter will focus on the role of pregnancy complications with altered nutrition during gestation in the maladaptive programming of β-cell mass and function in the offspring.
Keyphrases
- physical activity
- type diabetes
- high fat diet
- healthcare
- public health
- single cell
- pregnancy outcomes
- gene expression
- induced apoptosis
- mental health
- birth weight
- health information
- insulin resistance
- preterm infants
- cardiovascular disease
- risk factors
- cell cycle arrest
- metabolic syndrome
- risk assessment
- gestational age
- signaling pathway
- skeletal muscle
- climate change
- weight loss