Identification and validation of novel biomarkers and therapeutics for pulpitis using connectivity mapping.

Banan Al-NatourRobby RankinRobyn McKennaHayley McMillanShu-Dong ZhangImad AboutAsma A KhanJohnah C GaliciaFionnuala T LundyIkhlas A El-Karim

Published in: International endodontic journal (2021)

AQP9, MT1H and CCL21 were identified and validated as novel biomarkers for pulpitis. Fluvastatin and dequalinium chloride identified by the ssCMap as potential therapeutics for pulpitis reduced selected pulpitis biomarkers in an ex vivo pulpitis model. In vivo testing of these licenced drugs is warranted.

Keyphrases

small molecule
high resolution
multiple sclerosis
risk assessment
functional connectivity
high density
human health