The effects of N 6 -methyladenosine RNA methylation on the nervous system.

Epitranscriptomics, also known as "RNA epigenetics", is a type of chemical modification that regulates RNA. RNA methylation is a significant discovery after DNA and histone methylation. The dynamic reversible process of m 6 A involves methyltransferases (writers), m 6 A binding proteins (readers), as well as demethylases (erasers). We summarized the current research status of m 6 A RNA methylation in the neural stem cells' growth, synaptic and axonal function, brain development, learning and memory, neurodegenerative diseases, and glioblastoma. This review aims to provide a theoretical basis for studying the mechanism of m 6 A methylation and finding its potential therapeutic targets in nervous system diseases.