Login / Signup

Intratumoral presence of the genotoxic gut bacteria pks + E. coli, Enterotoxigenic Bacteroides fragilis, and Fusobacterium nucleatum and their association with clinicopathological and molecular features of colorectal cancer.

Jihoon E JooYen Lin ChuPeter GeorgesonRomy WalkerKhalid MahmoodMark ClendenningAaron L MeyersJulia ComoSharelle JoselandSusan G PrestonNatalie DiepenhorstJulie TonerDanielle J IngleNorelle L SherryAndrew MetzBrigid M LynchRoger L MilneMelissa C SoutheyJohn L HopperAung-Ko WinFinlay A MacraeIngrid M WinshipChristophe RostyMark A JenkinsDaniel D Buchanan
Published in: British journal of cancer (2024)
are associated with CRCs harbouring the APC:c.835-8 A > G somatic mutation, suggesting that this mutation is specifically related to DNA damage from colibactin-producing E.coli exposures. F. nucleatum was associated with both hereditary and sporadic MMRd subtypes, suggesting the MMRd tumour microenvironment is important for F. nucleatum colonisation irrespective of its cause.
Keyphrases
  • dna damage
  • escherichia coli
  • stem cells
  • oxidative stress
  • late onset
  • air pollution
  • copy number
  • amyotrophic lateral sclerosis
  • gene expression
  • dna methylation
  • single molecule