Neutralization of insulin by photocleavage under high vacuum.

Jonas SchättiMoritz KrieglederMaxime DebiossacMichael KerschbaumPhilipp GeyerMarcel Mayor Markus Arndt Valentin Köhler

Published in: Chemical communications (Cambridge, England) (2019)

Charge reduction and neutralization of electro-sprayed peptides are realized by selective gas-phase photocleavage of tailored covalent tags. The concept is demonstrated with four model peptides in positive and negative ion modes and tagged insulin as the largest construct.

Keyphrases

type diabetes
glycemic control
amino acid
smoking cessation
high speed
adipose tissue