Novel parent-of-origin-specific differentially methylated loci on chromosome 16.

Katharina V SchulzePrzemyslaw SzafranskiHarry LesmanaRobert J HopkinAaron HamvasJennifer A WambachMarwan ShinawiGladys ZapataClaudia M B CarvalhoQian LiuJustyna A KarolakJames R LupskiNeil A HanchardPrzemyslaw Szafranski

Published in: Clinical epigenetics (2019)

Using high-resolution bisulfite sequencing to evaluate DNA methylation across chromosome 16, we found evidence for novel candidate imprinted loci on chromosome 16 that would not be evident in array-based assays and could contribute to the birth defects observed in patients with upd(16)mat or in ACDMPV.

Keyphrases

genome wide
copy number
high resolution
dna methylation
high throughput
genome wide association study
gene expression
genome wide association
single cell
tandem mass spectrometry
high density
preterm birth