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Recent progress in drying technologies for improving the stability and delivery efficiency of biopharmaceuticals.

Fakhrossadat EmamiMahsa Keihan ShokoohSeyed Jamaleddin Mostafavi Yazdi
Published in: Journal of pharmaceutical investigation (2022)
With the aim of treating either infectious respiratory diseases or systemic disorders, inhaled biopharmaceuticals reduce both therapeutic dose and cost of therapy. Drying methods in the presence of optimized protein/stabilizer combinations, produce solid dosage forms of proteins with greater stability. A suitable drying method was chosen, and the process parameters were optimized based on the route of protein administration. With the ongoing trend of addressing deficiencies in biopharmaceutical production, developing new methods to replace conventional drying methods, and investigating novel excipients for more efficient stabilizing effects, these products have the potential to dominate the pharmaceutical industry in the future.
Keyphrases
  • protein protein
  • cystic fibrosis
  • current status
  • small molecule
  • mesenchymal stem cells
  • climate change