MicroRNA-351-5p aggravates intestinal ischaemia/reperfusion injury through the targeting of MAPK13 and Sirtuin-6.
Yupeng HuXufeng TaoXu HanLina XuLianhong YinHuijun SunYan QiYouwei XuJinyong PengPublished in: British journal of pharmacology (2018)
Our data showed that miR-351-5p aggravated II/R injury by promoting intestinal mucosal oxidative stress, inflammation and apoptosis by targeting MAPK13 and sirtuin-6.These data provide new insights into the mechanisms regulating II/R injury, and of miR-351-5p could be considered as a novel therapeutic target for such injury.
Keyphrases
- oxidative stress
- diabetic rats
- signaling pathway
- electronic health record
- dna damage
- ischemia reperfusion injury
- induced apoptosis
- big data
- acute myocardial infarction
- endoplasmic reticulum stress
- heart failure
- cell death
- acute coronary syndrome
- left ventricular
- cerebral ischemia
- coronary artery disease
- brain injury
- artificial intelligence
- subarachnoid hemorrhage