Genomewide Association Studies of LRRK2 Modifiers of Parkinson's Disease.
Dongbing LaiBabak AlipanahiPierre FontanillasTae-Hwi Schwantes-AnJan AaslyRoy N AlcalayGary W BeechamDaniela BergSusan BressmanAlexis BriceKathrin BrockmanLorraine ClarkMark CooksonSayantan DasVivianna Van DeerlinJordan FollettMatthew J FarrerJoanne TrinhThomas GasserStefano GoldwurmEmil GustavssonChristine KleinAnthony E LangJ William LangstonJeanne LatourelleTimothy LynchKaren MarderConnie MarrasEden R MartinCory Y McLeanHelen Mejia-SantanaEric MolhoRichard H MyersKaren NuytemansLaurie OzeliusHaydeh PayamiDeborah RaymondEkaterina RogaevaMichael P RogersOwen A RossAli SamiiRachel Saunders-PullmanBirgitt SchüleClaudia SchulteWilliam K ScottCaroline TannerEduardo TolosaJames E TomkinsDolores VilasJohn Q Trojanowskinull nullRyan UittiJeffery M VanceNaomi P VisanjiZbigniew K WszolekCyrus P ZabetianAnat MirelmanNir GiladiAvi Orr UrtregerPaul CannonBrian FiskeTatiana ForoudPublished in: Annals of neurology (2021)
This study suggests that variants within or near CORO1C may modify the penetrance of LRRK2 mutations. In addition, common Parkinson's disease associated variants collectively increase the penetrance of LRRK2 mutations. ANN NEUROL 2021;90:82-94.
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