Circulating neprilysin hypothesis: A new opportunity for sacubitril/valsartan in patients with heart failure and preserved ejection fraction?

Josep LupónEvelyn Santiago-VacasGermán CedielPau CodinaMar DomingoElena Revuelta-LópezElisabet ZamoraGiosafat SpitaleriJavier SantesmasesJulio NúñezAntoni Bayes-Genis

Published in: PloS one (2021)

sNEP prognostic value in patients with HF and LVEF >57% outperforms that observed in patients with lower LVEF. Precision medicine using sNEP may identify HF patients with preserved LVEF that may benefit from treatment with sacubitril/valsartan.

Keyphrases

ejection fraction
aortic stenosis
acute heart failure
coronary artery disease
atrial fibrillation
aortic valve