Cellular Immune Profiling of Lung and Blood Compartments in Patients with SARS-CoV-2 Infection.

Letizia SantinelliAlessandro LazzaroFrancesca SciarraLuca MaddaloniFederica FrascaMatteo FracellaSonia MorettiAlessandra BorsettiGinevra BuganiFrancesco AlessandriVeronica ZullinoFranco RubertoFrancesco Pugliese Leonardo SorrentinoDaniele GianfrilliAndrea IsidoriMary Anna Venneri Claudio Maria Mastroianni Giancarlo Ceccarelli Gabriella d'Ettorre

Published in: Pathogens (Basel, Switzerland) (2023)

These results show that the immune cellular profile in blood and pulmonary compartments was similar in survivors and non-survivors of COVID-19. T lymphocyte levels were reduced, but resulted highly immune-activated in the lung compartment of patients who faced a fatal outcome.

Keyphrases

coronavirus disease
sars cov
young adults
pulmonary hypertension
respiratory syndrome coronavirus
single cell