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Probing the evolutionary robustness of two repurposed drugs targeting iron uptake in Pseudomonas aeruginosa.

Chiara RezzoagliDavid WilsonMichael WeigertStefan WyderRolf Kümmerli
Published in: Evolution, medicine, and public health (2018)
Our work highlights that antivirulence treatments are not evolutionarily robust per se. Instead, evolutionary robustness is a relative measure, with specific treatments occupying different positions on a continuous scale.
Keyphrases
  • pseudomonas aeruginosa
  • genome wide
  • cystic fibrosis
  • biofilm formation
  • cancer therapy
  • single molecule
  • acinetobacter baumannii
  • molecular dynamics simulations
  • staphylococcus aureus
  • drug delivery
  • drug resistant