Melatonin alleviates particulate matter-induced liver fibrosis by inhibiting ROS-mediated mitophagy and inflammation via Nrf2 activation.

Laiyu ZhuQi ZhangCong HuaXinxin Ci

Published in: Ecotoxicology and environmental safety (2023)

These data suggest that melatonin effectively inhibits PM2.5-induced liver fibrosis by activating Nrf2 and inhibiting ROS-mediated mitophagy and inflammation.

Keyphrases

liver fibrosis
particulate matter
oxidative stress
diabetic rats
air pollution
signaling pathway
high glucose
dna damage
cell death
reactive oxygen species
drug induced
nlrp inflammasome
electronic health record
endothelial cells
heavy metals
machine learning
artificial intelligence