Sulforaphane Ameliorates Limb Ischemia/Reperfusion-Induced Muscular Injury in Mice by Inhibiting Pyroptosis and Autophagy via the Nrf2-ARE Pathway.

Huanhuan Sun Jueqiong Wang Wei Bi Feng Zhang Kui Chi Long Shi Tao Yuan Kai Ma Xiang Gao

Published in: Evidence-based complementary and alternative medicine : eCAM (2022)

SFN activates the Nrf2-ARE pathway, and thereby inhibits pyroptosis and autophagy and provides a novel therapeutic strategy for the limb I/R-induced muscle tissue damage.

Keyphrases

oxidative stress
diabetic rats
signaling pathway
high glucose
cell death
endoplasmic reticulum stress
drug induced
skeletal muscle
endothelial cells
type diabetes
metabolic syndrome
resistance training