Effect of N-acetyl cysteine in children with metabolic dysfunction-associated steatotic liver disease-A pilot study.

P Babu BalagopalRohit KohliVikas UppalLauren AverillChetan ShahKatherine McGooganMatthew Di GuglielmoMichael GoranMd Jobayer Hossain

Published in: Journal of pediatric gastroenterology and nutrition (2024)

Sixteen-week NAC treatment was well tolerated in children with obesity and MASLD and led to improvements in oxidative stress, inflammation and IR and liver outcomes. The results from this pilot study support further investigation of NAC as a therapeutic agent in children with MASLD.

Keyphrases

oxidative stress
young adults
transcription factor
type diabetes
metabolic syndrome
weight loss
clinical trial
dna damage
induced apoptosis
skeletal muscle
adipose tissue
weight gain
signaling pathway
study protocol
endoplasmic reticulum stress
replacement therapy