Are bone turnover markers associated with volumetric bone density, size, and strength in older men and women? The AGES-Reykjavik study.
Elisa A MarquesV GudnasonG SigurdssonT LangF JohannesdottirK SiggeirsdottirL LaunerG EiriksdottirT B HarrisPublished in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2015)
Serum CTX, OC, and P1NP were weakly correlated with lumbar spine and FN areal and volumetric BMD and strength measures. Most of the bone size indices were not associated with BTMs; thus, the selected bone remodeling markers do not reflect periosteal bone formation. These results confirmed the limited ability of the most sensitive established BTMs to predict bone structural integrity in older adults.