Oncohistone Mutations Occur at Functional Sites of Regulatory ADP-Ribosylation.
Dan HuangCristel V CamachoSara MartireAnusha NagariRohit SetlemXuan GongAndrea D EdwardsShu-Ping ChiuLaura A BanaszynskiW Lee KrausPublished in: Cancer research (2022)
This study identifies cancer-driving mutations in histones as sites of PARP1-mediated ADP-ribosylation in breast and ovarian cancers, providing a molecular pathway by which cancers may subvert the growth-regulating effects of PARP1.