Methylation and transcriptome analyses construct a prognostic model and reveal the suppressor role of VMO1 in lung adenocarcinoma.

Lishui WangMaopeng YinZeyu ZhangShichao LiuYingjie LiuXueyan GengGuixi Zheng

Published in: Cellular signalling (2024)

In summary, our experiments constructed a prognostic model with high capacity for risk prediction in LUAD patients. VMO1 had a malignant suppressor role in LUAD cells. The correlation between risk score and TME might elucidate a potential mechanism of oncogenesis and provide an avenue for further therapeutic targets.

Keyphrases

genome wide
end stage renal disease
ejection fraction
induced apoptosis
newly diagnosed
single cell
peritoneal dialysis
prognostic factors
gene expression
wastewater treatment
rna seq
cell cycle arrest
cell proliferation
human health
cell death
signaling pathway
pi k akt