Carbohydrate antigen 125 on epicardial fat and its association with local inflammation and fibrosis-related markers.

Sonia EirasRafael de la EspriellaXiaoran FuDiego Iglesias-ÁlvarezRumeysa BasdasJ R Núñez-CaamañoJ M Martínez-CereijoL ReijaA L FernándezDavid Sánchez-LópezGema MiñanaJulio NúñezJosé R González-Juanatey

Published in: Journal of translational medicine (2024)

Epicardial cells express CA125, which is positively associated with inflammatory and fibroblast markers in epicardial adipose tissue. These results suggest that CA125 may be biologically involved in HF progression (transition from adipogenesis to fibrosis).

Keyphrases

adipose tissue
oxidative stress
induced apoptosis
cell cycle arrest
high fat diet
protein kinase
liver fibrosis
type diabetes
heart failure
metabolic syndrome
atrial fibrillation
pi k akt
high fat diet induced