Concordance of the 21-gene assay between core needle biopsy and resection specimens in early breast cancer patients.
Peng QiYu YangQian-Ming BaiTian XueMin RenQian-Lan YaoWen-Tao YangXiao-Yan ZhouPublished in: Breast cancer research and treatment (2021)
A modest- to- strong correlation of ER, PR, HER-2 and Ki-67 gene expression and RS between CNBs and resection specimens was observed in the present study. The 21-gene RS test could be reliably performed on CNBs. ER, PR and HER-2 status showed remarkable concordance between the IHC and RT-PCR analyses. The concordance between paired samples was high for the IHC ER, PR and Ki-67 results and low for HER-2.
Keyphrases
- gene expression
- end stage renal disease
- early breast cancer
- endoplasmic reticulum
- estrogen receptor
- ultrasound guided
- fine needle aspiration
- genome wide
- breast cancer cells
- ejection fraction
- chronic kidney disease
- newly diagnosed
- copy number
- dna methylation
- neoadjuvant chemotherapy
- peritoneal dialysis
- high throughput
- prognostic factors
- squamous cell carcinoma
- genome wide identification
- rectal cancer
- lymph node