Chimeric antigen receptor T cells in the fast lane among autoimmune disease therapies.

Published in: Clinical & translational immunology (2024)

In this commentary, we highlight recent studies demonstrating the feasibility and promise of chimeric antigen receptor (CAR) T-cell therapy in treating a number of autoimmune disorders including systemic lupus erythematosus and compare CAR T cells to other therapies aimed at depleting B-lineage cells in treating such diseases.

Keyphrases

cell therapy
systemic lupus erythematosus
induced apoptosis
multiple sclerosis
stem cells
cell cycle arrest
mesenchymal stem cells
disease activity
drug induced
endoplasmic reticulum stress
signaling pathway
single cell
big data
cell death
case control
rheumatoid arthritis
pi k akt
cell fate