Δ9 -Tetrahydrocannabinolic acid alleviates collagen-induced arthritis: Role of PPARγ and CB1 receptors.

Belén PalomaresMartín Garrido-RodriguezClaudia Gonzalo-ConsuegraMaría Gómez-CañasSuwipa Saen-OonRobert SolivaJuan A ColladoJavier Fernández-RuizGaetano MorelloMarco A CalzadoGiovanni AppendinoEduardo Muñoz

Published in: British journal of pharmacology (2020)

Δ9 -THCA-A modulates CB1 receptors through the orthosteric and allosteric binding sites. In addition, Δ9 -THCA-A exerts anti-arthritis activity through CB1 receptors and PPARγ pathways, highlighting its potential for the treatment of chronic inflammatory diseases such as rheumatoid arthritis.

Keyphrases

rheumatoid arthritis
insulin resistance
disease activity
small molecule
high glucose
diabetic rats
oxidative stress
ankylosing spondylitis
metabolic syndrome
endothelial cells
adipose tissue
skeletal muscle
systemic sclerosis
idiopathic pulmonary fibrosis