α-Ketoglutarate improves cardiac insufficiency through NAD + -SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice.

, the SIRT-PINK1 and SIRT1-GPX4 signaling pathways are activated to promote mitophagy and inhibit ferroptosis in cardiomyocytes, which ultimately alleviates cardiomyocyte damage.