Association of Coding Variants in Hydroxysteroid 17-beta Dehydrogenase 14 (HSD17B14) with Reduced Progression to End Stage Kidney Disease in Type 1 Diabetes.

Josyf C Mychaleckyi Erkka ValoTakaharu IchimuraTarunveer Singh AhluwaliaChristian DinaRachel G MillerIvan G ShabalinBeata GyorgyJingJing CaoSuna Onengut-GumuscuEiichiro SatakeAdam M SmilesJani K HaukkaDavid-Alexandre TregouetTina CostacouKristina O'NeilAndrew D PatersonCarol ForsblomHillary A KeenanMarcus G PezzolesiMarlon PragnellAndrzej GaleckiStephen S Rich Erkka ValoRonald KleinBarbara E KleinKatalin SusztákTrevor J OrchardRon KorstanjeGeorge L KingSamy HadjadjPeter RossingJoseph V BonventrePer-Henrik GroopJames H WarramAndrzej S Krolewski

Published in: Journal of the American Society of Nephrology : JASN (2021)

HSD17B14 gene is mechanistically involved in diabetic kidney disease. The encoded sex steroid enzyme is a druggable target, potentially opening a new avenue for therapeutic development.

Keyphrases

type diabetes
copy number
genome wide
glycemic control
cardiovascular disease
insulin resistance
wound healing
dna methylation
genome wide identification
gene expression
metabolic syndrome
skeletal muscle
adipose tissue