Polyfunctional antigen specific CD4± T cell responses in Patients with HIV/AIDS and Histoplasmosis Immune Reconstitution Inflammatory Syndrome.

Maura ManionAfroditi BoulougouraNuha NaqviSilvia Lucena LageElizabeth RichardsChristopher GrivasElizabeth LaidlawSafia KuriakoseAna M Ortega-VillaSaber TadrosGregg RobyAdam RupertFrance GalindoMegan AndersonAlice PauGeorge DeepeVirginia SheikhIrini Sereti

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)

In the combination antiretroviral era, there are limited data regarding the pathogenesis of histoplasmosis immune reconstitution inflammatory syndrome (IRIS) in people with HIV. We immunologically characterized ten cases of histoplasmosis, four of whom developed histoplasmosis IRIS. CD4+ T-cells in histoplasmosis IRIS demonstrated a significant polyfunctional cytokine response to histoplasma antigen.

Keyphrases

hiv aids
antiretroviral therapy
human immunodeficiency virus
hiv infected
hiv positive
oxidative stress
hiv infected patients
case report
hepatitis c virus
machine learning