Exploring the Molecular Mechanism of Schisandrin C for the Treatment of Atherosclerosis via the PI3K/AKT/mTOR Autophagy Pathway.
Hong DuanHan LiTianyi LiuYuan ChenMengmeng LuoYing ShiJing ZhouMarwan M A RashedKe-Feng ZhaiLili LiZhao-Jun WeiPublished in: ACS omega (2024)
Atherosclerosis (AS) is a common cardiovascular disease that poses a major threat to health. Schisandra chinensis is a medicinal and edible plant that is commonly used to treat cardiovascular diseases. In this paper, HPLC was used to detect and analyze 5 different components in Schisandra chinensis . Network pharmacological predictions highlight the PI3K/AKT/mTOR pathway as an important pharmacological pathway. The effective ingredient Schisandrin C was screened by the molecular docking technique. ox-LDL-induced HUVECs were used to construct the atherosclerosis model for further experimental verification. The results showed that Schisandrin C interfered with the PI3K/AKT/mTOR autophagy pathway. This study lays a foundation for the further application of Schisandrin C in the prevention and treatment of atherosclerosis in the future.
Keyphrases
- cardiovascular disease
- molecular docking
- healthcare
- cell death
- oxidative stress
- type diabetes
- endoplasmic reticulum stress
- ms ms
- public health
- molecular dynamics simulations
- simultaneous determination
- high glucose
- metabolic syndrome
- health information
- replacement therapy
- combination therapy
- coronary artery disease
- diabetic rats
- climate change
- high performance liquid chromatography
- smoking cessation