Physical Activity Delays Obesity-Associated Pancreatic Ductal Adenocarcinoma in Mice and Decreases Inflammation.

Valentina Pita-GrisantiKelly DubayAli LahootiNiharika BadiOlivia UeltschiKristyn Gumpper-FedusHsiang-Yin HsuehIla LahootiMyrriah Chavez-TomarSamantha TerhorstSue E KnoblaughLei CaoWei HuangChristopher C CossThomas A MaceFouad ChoueiryAlice HintonJennifer M MitchellRosemarie SchmandtMichaela Onstad GrinsfelderKaren Basen-EngquistZobeida Cruz-Monserrate

Published in: bioRxiv : the preprint server for biology (2023)

PA alone or combined with diet-induced weight loss delayed the progression of PDAC and reduced systemic and adipose inflammatory signals. Therefore, obesity management via dietary interventions and/or PA, or modulating weight loss related pathways could prevent obesity-associated PDAC in high-risk obese individuals.

Keyphrases

weight loss
bariatric surgery
roux en y gastric bypass
physical activity
gastric bypass
high fat diet induced
insulin resistance
oxidative stress
metabolic syndrome
weight gain
type diabetes
glycemic control
obese patients
signaling pathway
depressive symptoms