Sodium metavanadate induced cognitive decline, behavioral impairments, oxidative stress and down regulation of myelin basic protein in mice hippocampus: Ameliorative roles of β-spinasterol, and stigmasterol.
Olamide Elizabeth AdebiyiJames Olukayode OlopadeFunsho Olakitike OlayemiPublished in: Brain and behavior (2018)
The findings of this study indicate a potential for stigmasterol, a bioactive compound from G. carpinifolia in improving cognitive decline, motor coordination, and ameliorating oxidative stress in vanadium-induced neurotoxicity.
Keyphrases
- cognitive decline
- diabetic rats
- oxidative stress
- mild cognitive impairment
- high glucose
- dna damage
- drug induced
- ischemia reperfusion injury
- induced apoptosis
- type diabetes
- endothelial cells
- white matter
- adipose tissue
- skeletal muscle
- multiple sclerosis
- metabolic syndrome
- amino acid
- climate change
- insulin resistance
- signaling pathway
- human health
- heat shock protein
- endoplasmic reticulum stress
- cerebral ischemia