Rituximab Treatment in Acute Disseminated Encephalomyelitis Associated with Salmonella Infection.
Ebru KacmazGurkan BozanKursat Bora CarmanOmer KilicMehmet Ozgur ArslanogluUgur ToprakAsli Kavaz TufanCoskun YararEner Çağrı DinleyiciPublished in: Case reports in pediatrics (2021)
Acute disseminated encephalomyelitis (ADEM) is an inflammatory, demyelinating, and rapidly progressive disorder of the central nervous system. This condition is also known as postinfectious encephalomyelitis, and it is characterized by multifocal lesions in the brain and spinal cord with widespread neurological findings. High doses of intravenous (IV) methylprednisolone, intravenous immunoglobulin (IVIG), and plasma exchange (PLEX) treatments comprise the first-line therapy. There are limited pediatric case reports refractory to standard treatment. Here, we present the case of a 17-year-old girl diagnosed with ADEM associated with Salmonella infection, which was treated with rituximab.
Keyphrases
- spinal cord
- high dose
- escherichia coli
- diffuse large b cell lymphoma
- respiratory failure
- drug induced
- spinal cord injury
- white matter
- oxidative stress
- brain injury
- chronic lymphocytic leukemia
- intensive care unit
- hodgkin lymphoma
- young adults
- aortic dissection
- subarachnoid hemorrhage
- cerebral ischemia
- extracorporeal membrane oxygenation
- childhood cancer