Pathologic and MRI analysis in acute atypical inflammatory demyelinating lesions.
Xavier AyrignacValérie RigauBenoit LhermitteThierry VincentNicolas Menjot de ChampfleurClarisse Carra-DalliereMahmoud CharifNicolas CollonguesJérôme de SezeSonia HebbadjGuido AhleHélène OesterléFrançois CottonFrançoise Durand-DubiefRomain MarignierSandra VukusicFrédéric TaitheMikael CohenAnne-Marie GuennocAnne KerbratGilles EdanBéatrice Carsin-NicolThibaut AllouDenis SablotEric ThouvenotAurélie RuetLaurent MagyMarie-Paule Boncoeur-MartelPierre LabaugeStéphane KremerPublished in: Journal of neurology (2019)
Although imaging findings in patients with atypical inflammatory demyelinating lesions are heterogeneous, some common features such as peripheral DWI hyperintense rim with open-rim enhancement and absence of oedema argue in favour of a demyelinating lesion and should preclude a brain biopsy. In this context, AQP4 staining is systematically preserved and argues against an AQP4-positive NMOSD. Moreover, long-term follow-up is characterized by low recurrence rate.
Keyphrases
- diffusion weighted imaging
- oxidative stress
- liver failure
- high resolution
- magnetic resonance imaging
- minimally invasive
- contrast enhanced
- neoadjuvant chemotherapy
- white matter
- respiratory failure
- ultrasound guided
- drug induced
- resting state
- magnetic resonance
- computed tomography
- radiation therapy
- free survival
- extracorporeal membrane oxygenation
- mass spectrometry
- hepatitis b virus
- acute respiratory distress syndrome
- chemotherapy induced
- blood brain barrier